Monday 3rd May
Microbiology Bldg, 720 Cumberland Street
Dr Allan Gamble
School of Pharmacy, University of Otago
‘Bioorthogonal chemical reactions for activation of prodrugs and diagnostics’
A bioorthogonal chemical reaction is a ‘click’ reaction between two carefully designed chemical reagents that can proceed, unhindered, in a living system. Traditionally these reactions have been used as ‘click-and-stick’ tools in chemical biology (e.g., bioconjugations and imaging). Our group is interested in designing ‘click-and-release’ type strategies for controlled drug delivery applications and diagnostics. We have identified a new and general bioorthogonal activation strategy based on the 1,3-dipolar cycloaddition of an azide-substituted self-immolative linker (SIL) and trans-cyclooctene (TCO). The development of this chemistry and the in vitro and in vivo applications using a tumour prodrug strategy will be presented. The ‘click-and-release’ approach could be extended to other areas of medicinal chemistry and chemical biology.