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Posted by Dr Allan Gamble on 28 April 2021 | Comments

12:00 Noon

Monday 3rd May

Room 208

Microbiology Bldg, 720 Cumberland Street



Dr Allan Gamble

School of Pharmacy, University of Otago

‘Bioorthogonal chemical reactions for activation of prodrugs and diagnostics’

A bioorthogonal chemical reaction is a ‘click’ reaction between two carefully designed chemical reagents that can proceed, unhindered, in a living system.  Traditionally these reactions have been used as ‘click-and-stick’ tools in chemical biology (e.g., bioconjugations and imaging).  Our group is interested in designing ‘click-and-release’ type strategies for controlled drug delivery applications and diagnostics.  We have identified a new and general bioorthogonal activation strategy based on the 1,3-dipolar cycloaddition of an azide-substituted self-immolative linker (SIL) and trans-cyclooctene (TCO).  The development of this chemistry and the in vitro and in vivo applications using a tumour prodrug strategy will be presented.  The ‘click-and-release’ approach could be extended to other areas of medicinal chemistry and chemical biology.