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Microbiology Logo Microbiology & Immunology
Te Tari Moromoroiti me te Ārai Mate

Professor Roslyn Kemp


Research interests:

Applied and molecular immunology, cancer immunobiology, vaccines – immunology and technology

Current research:

My research focuses on T cells as mediators of anti-tumour immunity and inflammation.  Specifically,  we study the role of inflammation and the unique features of different subsets of T cells and myeloid cells, focussing on cancer and gut-specific immune responses; and how these cell subsets are involved in patient outcome. We use high dimensional tools and analyses to study the networks of cells and molecules in the immune response

We are currently looking at T cell and myeloid cell subsets in colorectal cancer and inflammatory bowel disease to improve diagnosis, prognosis and treatment.  We are analysing the molecular signalling pathways in T cells.


Research projects 

My current areas of research are mucosal and tumour  immune responses, inflammation and T cell memory. 

Mucosal Immune Responses in Cancer and Inflammatory Diseases

  • Using immune responses in the tumour to predict patient outcome in colorectal cancer
  • Investigating T cell responses in inflammatory bowel disease patients
  • Using human intestinal organoids to model the gut immune response
  • Heterogeneity and plasticity of T cell subsets in the gut mucosa and their influence on anti-tumour immune responses
  • Generating gut-specific memory T cells through vaccination
  • Development of new analytical tools to study high dimensional immune data

CD8+ T Cell Memory

  • Interactions between naïve and memory T cell populations
  • Vaccination strategies to generate effective T cell memory populations

Molecular Pathways controlling T cells

  • Molecular signals controlling memory T cell development and maintenance
  • Signalling pathways in tumour immune responses

Kemp Lab 2019


Lab group 

Dr Andrew Highton

Postdoctoral Fellow 

Dr Kirsten Ward-Hartstonge

Cancer Research Trust John Gavin Postdoctoral Fellow

Dr Lisa Fan

Research Assistant

Postgraduate students

Janet Rhodes

PhD student

Jess Harte

PhD student

Justin Tirados

PhD student

Gemma Laws

PhD student

Doug Gaskarth

PhD student

Rory Costello

PhD student

Brad Devery

BSc Hons student

       
       
 

 

   
       
       
       

 


Other activities

 


Current sources of funding

  • Cancer Research Trust
  • School of Biomedical Sciences
  • Dunedin School of Medicine
  • University of Otago
  • Otago Medical Research Foundation