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Microbiology Logo Microbiology & Immunology
Te Tari Moromoroiti me te Ārai Mate

Associate Professor Roslyn Kemp


Research interests:

Applied and molecular immunology, cancer immunobiology, vaccines – immunology and technology

Current research:

My research focuses on T cells as mediators of anti-tumour immunity and inflammation.  Specifically,  we study the role of inflammation and the unique features of different subsets of T cells and myeloid cells, focussing on cancer and gut-specific immune responses; and how these cell subsets are involved in patient outcome. 

We are currently looking at T cell and myeloid cell subsets in colorectal cancer and inflammatory bowel disease to improve diagnosis, prognosis and treatment.  We are generating site-specific T cell memory using novel slow release vaccines and analysing the molecular signalling pathways required to maintain these populations.


Research projects 

My current areas of research are mucosal and tumour  immune responses and T cell memory.

Mucosal Immune Responses in Cancer and Inflammatory Diseases

  • Using immune responses in the lymph nodes and tumour to predict patient outcome in colorectal cancer
  • Investigating T cell responses in inflammatory bowel disease, Type 1 diabetes and spondylosing arthritis patients
  • T cell subsets in the gut mucosa and their influence on anti-tumour immune responses
  • Macrophage responses in colorectal cancer and inflammatory diseases, and in response to Vitamin D
  • Generating gut-specific memory T cells through vaccination

CD8+ T Cell Memory

  • Interactions between naïve and memory T cell populations
  • Molecular signals controlling memory T cell development and maintenance
  • Vaccination strategies to generate effective T cell memory populations

Lab group 

Ros lab 2016

photo - Kemp Lab past and present

Kirsten Ward Hartstonge

PGDipSci student 2013, PhD student 2014  - 

  • Winner NZASI Buck Award Immunology 2017
  • Genesis Professional Development Award 2017
  • Winner - Young Researcher Award NZ Society of Oncology 2016
  • Winner OMSRS PhD Award 2016
  • Winner OSMS Postgraduate Symposium PK Talk 2016
  • Awarded ASI Travel Award to attend ICI 2016
  • Awarded Lotteries Research Health PhD Scholarship 2014
  • Awarded Genesis Oncology Trust Post-graduate Scholarship 2014 (declined)
  • winner - Brenda Shore Award for Women 2014
  • winner - Todd Foundation Award for Excellence 2014

Sam Norton

BBiomedSci (Hons) student 2013, PhD student 2014 - 2017

  • 2nd place, OSMS Postgraduate Symposium Poster 2016
  • Sandy Smith Scholarship 2015
  • Genesis Oncology Trust Professional Development Award 2015
  • Webster Centre for Infectious Disease Travel Award 2014
  • ASI Travel Award 2014
  • Gut Health Network Travel Award 2014
  • winner OMSRS PhD Award 2014

Hamish Angus

BSc Hons student 2016; PhD student 2017 - 

Follow Hamish's progress in IBD research here

Simon Shirley

MSc student 2015 (with Sarah Hook); PhD student 2016 - (with Julie Cakebread and Ali Hodgkinson, AgResearch) 

 

Ginny Niemi

MSc student 2016 - 

  • 2nd Place BMS Postgraduate Symposium Poster 2017

Julia Leman

MSc student 2017 - 

  • 2nd Place BMS Postgraduate Symposium Short Talk 2017

 Gemma Laws

BBiomedSci Hons student 2014; MSc student 2017 - 

Emily Bisset


Other activities

Member, Ako Aotearoa Academy for Tertiary Teaching Excellence

Secretary-General, International Union of Immunological Societies

Otago School of Medical Sciences Kaitohutohu

Centre for Translational Cancer Research

Immunet

New Zealand Society of Oncology

Gut Health Network

University of Otago Supervisor of the Year 2013


Collaborations 

T Cell Responses in Colorectal Cancer -  Dr Mik Black, Department of Biochemistry, Prof John McCall, Department of Surgery 

Immune Scoring in Colorectal Cancer - Prof John McCall, Department of Surgery; Dr Michael Jameson, Waikato DHB

Enhancing T Cell Memory with Vaccination - Prof Sarah Hook, School of Pharmacy 

Gut Immune Responses in Patients with Inflammatory Disease - Dr Michael Schultz, Department of Medicine, Dr Grant Butt, Department of Physiology


Current sources of funding

Genesis Oncology Trust

Cancer Society of New Zealand

Otago School of Medical Sciences

Gastrointestinal Cancer Institute

Lottery Health Research

Roche / NZSO