Second Semester - 18 points
Molecular aspects of viral entry, replication, and assembly in host cells. Mechanisms by which viruses manipulate the hosts to multiply and cause disease.
Viruses are a diverse group of obligate intracellular pathogens that must infect a host to replicate. Viruses infect all forms of life and cause a wide array of human diseases such as flu, measles, hepatitis, polio, and rabies. Viruses manipulate host cell pathways to complete their life cycle and escape host-induced antiviral immune responses. The amazing diversity of viruses is underpinned by central themes of cell entry, genome replication, gene expression, virion assembly, and virion release.
This course is for students wanting a core paper on virology that includes course and team work on contemporary issues in virology from current diseases through to virus-host interactions. It also includes a lab course where students isolate and characterise a virus.
MICR 337 lectures will:
In the laboratory classes, students will:
This self-learning exercise will:
a. Presentation and essay (10%). In this self-learning exercise, students will research a given virology topic on their own, give a short group presentation to the class, and write an individual 1000-word essay.
b. Two laboratory assignments (20%). In the laboratory classes, students will isolate and purify their own virus from an environmental sample, determine its growth characteristics and host range, and identify it by visualizing it under an electron microscope. The assignments will be based on laboratory experiments. Failure to attend & complete the lab classes means you may not sit the final exam.
c. Final examination (70%). Students are given 9 questions listed below beforehand, 6 of which will form the basis of 3 hour final examination. The exam format will be “answer three either/or questions”.
MICR 221, MICR 223 or GENE 211
The course contact time involves two lectures per week for 13 teaching weeks of the second semester. There are two laboratory classes per week during academic weeks 9 – 12 of the second semester for a total of 48 hours, including lab work outside these hours as required.
Thursday, Friday 1-1.50pm (ARCH2)
Principles of Virology by Flint et al. (3rd or 4th edition)
Introduction to Modern Virology by Dimmock et al. (6th oand 7th edition)
In addition to hard copy, both are available as e-books in the Health Sciences Library and Science Library.
Students are encouraged to contact staff by email to make arrangements for a time to discuss course-related matters.
For more information on this course, please contact Dr Matloob Husain.