Infectious diseases, antimicrobial resistance, host-pathogen interaction, microbial pathogens, nanomedicines
Our research is focused on recalcitrant ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens; especially hard-to-treat clinical isolates involved in multidrug resistance, biofilm infections and persistence. We are especially interested in bacteria that have been categorized as "critical" priority pathogens by the World Health Organization. This includes multidrug resistant organisms that cause severe and often deadly infections and therefore pose an enormous threat in hospitals.
To address this issue, our research focuses on fighting infectious diseases and tackling antimicrobial resistance using innovative and interdisciplinary approaches.
Our lab seeks to 1) understand how microbes cause disease, 2) fight antimicrobial resistance with novel nanomedicines, and 3) develop new antimicrobial strategies.
|Dr. Sam Wardell||Dr. Rajesh Lamichhane|| Nikita Lyons
Dr. Shilpa Nair
|Postdoctoral Fellow||Postdoctoral Fellow||Assistant Research Fellow||Assistant Research Fellow|
4th Year students
Maddie Hardie Boys
|Research Assistant (RA)|
- Minati Choudhury (PhD Dentistry; Co-supervised - PI: Prof. Tompkins); 2023 - (Current location: International Medical University Malaysia)
- Shuying Wee; BBiomedSc(Hons); 2022
- Jess Henricks; BSc(Hons) Microbiology; 2022
- Tiu Cullen; BSc(Hons) Microbiology; 2022
- Bianca Tawatao; BSc(Hons) Microbiology; 2022
- Claude Vincent; BSc(Hons) Microbiology; 2021
- Finn Dusterwald; DipSci Genetics; 2021
- Deborah Yung; BSc(Hons) Microbiology; 2020
- Alana Hampson; BSc(Hons) Microbiology; 2020
- Sophie Qiu; BBiomedSc(Hons); 2020
Interested candidates with a BSc(Hons) or MSc degree are highly encouraged to apply if their research interest and experience matches any of the following themes: Microbiology, Immunology, Biochemistry, Genetics, or Bioinformatics.
All candidates must be eligible for admission to the University of Otago and apply for a MSc or PhD scholarship (https://www.otago.ac.nz/graduate-research/scholarships/index.html). The scholarship is available to both domestic and international students. International students should have a look at the International Office (https://www.otago.ac.nz/international/index.html) for entry requirements and contact the lab beforehand.
If you are interested in joining our lab, please send a cover letter including current research interests, a CV including all published work, a summary of previous research (if applicable), full academic transcripts, and contact information for two-three references.
A few relevant publications are listed below
(for a full publication list, please visit our profile on PubMed or our website):
Wolfmeier H, Wardell SJT, Liu LT, Falsafi R, Draeger A, Babiychuk EB, Pletzer D, Hancock REW
Front Microbiol. 10.3389/fmicb.2022.867449
Nielsen J*, Alford MA*, Yung DBY*, Molchanova N, Fortkort J, Lin J, Diamond G, Hancock REW, Jenssen H, Pletzer D, Lund R, Barron A.
ACS Infect Dis. 10.1021/acsinfecdis.1c00536
Harfoot R, Yung DBY, Anderson WA, Wild CEK, Coetzee N, Hernández LC, Lawley B, Pletzer D, Derraik JGB, Anderson YC, Quiñones-Mateu ME.
Yung DBY, Sircombe KJ, Pletzer D.
Mol Microbiol. 10.1111/mmi.14699
Pletzer D, Mansour SC, Hancock REW.
PLoS Pathog. 14(6):e1007084
*authors contributed equally as first author; italic = corresponding author; underline = lab members