First Semester - 18 points
Fundamental concepts in microbiology, building from the characteristics of microorganisms, through the handling and containment of microorganisms, to medical microbiology and immunology.
Microbes are all around us, all over us and all over every surface on earth. Microbes compose greater than 50% of life forms on our planet and yet it is estimated that only 1% have been identified and studied. We can’t live without microbes and they benefit our lives immensely.
Many of the microbes that surround us can cause disease and our immune system helps protect us from these microbes. The specialised cells of the immune system work as key defenders, protecting us from infection and disease.
MICR 221 will introduce you to the wonderful world of Microbiology and Immunology. You will learn about the immune system and the key cells and pathways of the immune system and also learn about the world of microbes.
The labs will teach you essential skills in handling and manipulating microorganisms and include looking at the treatment of microbial infections with different pharmaceutical preparations.
MICR 221 is essential if you want to carry on in Microbiology but it is also a useful addition to a wide variety of courses.
MICR 221 is a 32-lecture course that gives you a general introduction to Microbiology and Immunology. Lectures cover the following areas:
1. Physical and chemical requirements of microbial growth
2. Bacterial nutrition
3. The two sides of bacterial endospores
4. Physical control methods
5. Chemical control methods
6. Powering the bacterial cell through polymer breakdown
7. Transport across the bacterial membrane: the importance of membrane proteins in bacterial growth
8. Metabolic flux in Escherichia coli
9. Pump it up: proton pumps and the chemiosmotic hypothesis
10. ATP generation by a nanomolecular machine: the F1F0 ATP synthase
12. Impact of symbiosis on human health and disease
13. Impact of microbe, host, and medicine on disease
14. Food-borne diseases
15. Respiratory infections
16. Sexually transmitted diseases
17. Microbial virulence factors and their host targets
18. Introduction to the immune system
19. Antigen acquisition
20. The major histocompatibility complex (MHC)
21. Antigen presentation and costimulation
22. T cells
23. B cells
24. Effector cells of the immune system
25. Immune tolerance
26. An introduction to the diversity and abundance of viruses: there is more to viruses than a phage
27. The emergence and evolution of viruses: where do new viruses come from?
28. How do viruses transmit from host to host?
29. Virus transmission within a host and the targeting of susceptible cells
30. The principles of expression and replication of viruses with RNA genomes
31. Viruses with DNA genomes and the concept of host manipulation
32. Antiviral drugs: the targeting of key steps in viral replication
The MICR 221 paper includes a 6-lab course. The labs aim to teach you fundamental laboratory skills and reinforce concepts discussed in lectures. You will learn basic bacterial culture techniques, how to grow bacteria, how to estimate bacterial numbers and how to identify bacteria. You will gain microscope and staining skills and visualise microbes using the microscope. The labs will also see you look at medically important microbes, including a look at the bacteria on your own skin and a look at pharmaceutical products that can be used to control microbe infections. The labs will see you also learn eukaryotic microbes such as fungi, protozoa and algae.
The MICR 221 lab course covers:
CELS 191; CHEM 191 or CHEM 111; 36 further 100-level points
Prescott's Microbiology by Wiley, Sherwood and Woolverton, 10th edition, 2017, McGraw-Hill Publishers
Kuby Immunology, 7th edition, 2013, Palgrave Macmillan
Students are encouraged to contact staff by email to make arrangements for a time to discuss course-related matters.
For more information on this course, please contact Dr Judith Bateup.