1:00 pm, Monday, 21 August
Room BIG13, Ground Floor
Biochemistry Building
710 Cumberland St
Nils Birkholz
Microbiology & Immunology
Diverse regulation strategies govern bacterial defence and phage counter-defence
Bacteria are under constant threat of attack by their viral predators, phages. This has led to the evolution of various bacterial defence systems, including restriction–modification and CRISPR–Cas. Phages in turn use counter-defences such as anti-CRISPR proteins to neutralise host defence. However, all this weaponry comes at a cost, necessitating tight control. In this seminar, I will present my research on the multi-layered, and sometimes unexpected, regulation strategies – transcriptional, post-transcriptional and epigenetic – that are involved in the deployment of bacterial defence and phage counter-defence.
