Monday, 15 March
12:00 Noon
720 Cumberland Street, 2nd Floor, Room 208
Microbiology Bldg.
'Insights from DNA methylomes and cancer
metastasis'
We performed the first genome-wide study to provide single-nucleotide resolution DNA
methylation profiles in human neutrophils and showed existence of widespread inter-individual
variation in epigenetic marks in normal population. My work has also highlighted the epigenetic
landscape of zebrafish brain and liver and opened new avenues for using this model to further
understand the biology of DNA methylation. Further, our recent work enabled detection of
aberrant driver DNA methylation changes in metastatic melanomas and role of DNA
methylation in regulating PD-L1 expression in melanoma. We also have started identifying
epigenetic drivers of metastasis in colorectal and lung cancers. These findings will be useful to
understand the role of driver epigenetic events in cancer metastasis. My group is also active
and interested in developing novel tools to facilitate epigenomic analysis. In this talk, I will
present the key findings from some of our works over the years and briefly elaborate on some
future directions of our work in understanding role of DNA methylation events in metastasis
and treatment resistance in cancer. While describing the results, I would also mention the
steps and critical point in my career so far that might be of interest to students and early
career scientists.
