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Microbiology Logo Microbiology & Immunology
Te Tari Moromoroiti me te Ārai Mate

Fueling mycobacterial persistence

Adaptation of Mycobacterium tuberculosis to hypoxia and low energy conditions

Our laboratory is focused on two fundamental aspects of Mycobacterial physiology:

1. Determining how Mycobacterium tuberculosis and other pathogenic microorganisms metabolize and generate energy in host tissues

  • What energy sources do pathogenic microorganisms use in the host?

  • What are the mechanisms that pathogenic microorganisms use to generate energy?

  • How do aerobic pathogens survive in host tissues that are hypoxic?

  • What are the signalling pathways and how are the controlled?

Recent papers:

2. Deciphering the mechanisms Mycobacterium tuberculosis uses to slow metabolism/growth in response to various environmental cues

  • How do mycobacteria uncouple metabolism from growth?

  • What role do toxin-antitoxin modules play in this process?

Group members

Dr Michael Petridis, Postdoctoral fellow,

Liam Harold, PhD Candidate,

Reuben Vercoe, PhD Candidate,

Kiel Hards, PhD candidate,

Zoe Williams, PhD candidate,

Please enquire to obtain more specific information on these projects: