My current project looks at capitalizing on proteins derived from lytic phages to harness their bactericidal activity against antibiotic resistant gram-negatives. Our aim is to build a respository of proteins from phage that can be combined randomly to build libraries that will then be assessed for their efficacy in either killing or inhibiting the growth of the phytopathogen Pseudomonas syringae pv. actinidiae.
L.M. Malone, S. L. Warring, S. A. Jackson, C. Warnecke, P. P. Gardner, L. F. Gumy and P. C. Fineran, “A jumbo phage that forms a nucleus-like structure evades CRISPR-Cas DNA targeting but is vulnerable to type III RNA based immunity”, Nature Microbiology, 2020, 5, 48 – 55.
J. K. Wojtus, R. A. Frampton, S. L. Warring, H. Hendrickson and P. C. Fineran, “Genome sequence of a jumbo bacteriophage that infects the kiwifruit phytopathogen Pseudomonas syringae pv. Actinidiae”, Microbiology Resource Announcements, 2019, 8(22), e00224-19.
D. E. Jaskólska, D. F. Brougham, S. L. Warring, A. J. McQuillan, J. S. Rooney, K. C. Gordon, and C. J. Meledandri, “Competition driven ligand exchange: New processes and reactors for facile functionalization of nanoparticles and nanoparticle clusters without colloidal destabilization”, ACS Applied Nanomaterials, 2019, 2(4), 2230 – 2240. [IF = not issued]
I. Mutreja, S. L. Warring, K. S. Lim, T. Swadi, K. Clinch, J. M. Mason, C. R. Sheen, S. T. Chambers, G. B. Evans, M. L. Gerth, A. G. Miller and T. B. F. Woodfield, “Biofilm inhibition via delivery of novel methylthioadenosine nucleosidase inhibitors from PVA-tyramine hydrogels while supporting mesenchymal stromal cell viability”, ACS Biomaterials Science & Engineering 2019, 5(2), 748 - 758. [IF = 4.4]
S. A. Murugayah*, S. L. Warring* and M. L. Gerth "Optimisation of a highthroughput fluorescence-based assay for quorum-quenching acylases", Analytical Biochemistry 2019, 566, 10 – 12, doi: 10.1016/j.ab.2018.10.029, * these authors contributed equally to this work. [IF = 2.3]
S. L. Warring, M. Krasowska, D.A. Beattie and A.J. McQuillan, "Adsorption of a PEO surfactant on silica studied with in situ silica particle film ATR-IR spectroscopy and colloid probe AFM", Langmuir 2018, 34(45), 13481 – 13490. [IF = 3.8]
S. L. Warring, D. A. Beattie, and A. J. McQuillan, "Siloxane-to-silanol interconversion during room temperature hydration/dehydration of amorphous silica films observed by ATR-IR and TIR-Raman spectroscopy”, Langmuir 2016, 32(6), 1568 – 1576. [IF = 3.8, cited 34 times]