Applied immunology, medical microbiology, microbial pathogenesis
Dr McConnell is a Senior Research Fellow in the Department of Microbiology and Immunology. Current research in her group, as part of a wider Ag Research MBIE funded project (with Aladin Bekhit Food Science and Alan Carne Biochemistry), is primarily centered on the immunomodulatory effects of sheep milk in comparison with cow and goat milk, along with the microbiological status of the sheep milk. The sheep industry is a relatively young industry in New Zealand and the milk is predominantly used for cheese making in addition to some baby formula for the Chinese market. As part of the project she is co-supervising a PhD student Keegan Burrow from the Food Science Department who is investigating the bioavailability of minerals in sheep milk.
As well, Dr McConnell has an interest in the normal microflora of the gastrointestinal tract and is continuing some collaborative work with Dr Heather Brooks in the Department of Microbiology and Immunology on necrotizing enterocolitis (NEC). NEC is an acquired intestinal disease primarily found in premature neonates and which has a high mortality rate. At present, it is a disease of unknown origin, although many factors including microbes, an immature intestinal epithelial barrier and an immature host defense system have been implicated. Current research is centred around the use of probiotic strains of bacteria and how they may prevent disease.
Newer research in the laboratory is centered around collaborations with the Departments of Pharmacy (Dr Greg Walker)and Chemistry (Dr Jaydee Cabral). We have a fourth year student (Sasheen Dowlath) who is investigating the antimicrobial effects of nanofibres made with a variety of different polymers with the ultimate aim of using any with antimicrobial properties as coatings for medical devices.
Jodie Fleming is in thesis only year of her Masters degree and is investigating the effects of commensal and pathogenic bacteria on wound healing using a thermal wound in 3D human skin equivalents.
We are also hoping to use this model, in association with Jaydee Cabral, to investigate some novel delivery systems to deliver vascular endothelial growth factor to increase the rate of healing.
Sonya Mros is the senior research technician and lab manager for the group and assists the students with their projects and learning new techniques as well as taking the lead role in externally funded projects
K. Ryder, A. Bekhit, M. McConnell and A. Carne Towards generation of bioactive peptides from meat industry waste proteins: generation of peptides using commercial microbial proteases Food Chemistry 208:42-50 (2016)
C.S.F. Bah, A. Carne, M. A. McConnell, S MRos and A. Bekhit, Production of Bioactive Peptide Hydrolysates from Deer, Sheep, Pig and Cattle Red Blood Cell Fractions Using Plant and Fungal Protease Preparations Food Chemistry 202: 458-466 (2016)
Bekhit A.E. A., S. Mros, M.A. Ali and M. McConnell Chitosan is a highly effective in vitro antibacterial agent against the strains of bacteria causing footrot but is not effective in treating stage four footrot on farm. 2015 Proceedings of the New Zealand Society of Animal Production. Vol 75: 172-174
M. Ha, M. Sabherwal, E. Duncan, S. Stevens, P. Stockwell,M. McConnell, A. Bekhit, A. Carne In-Depth Characterization of Sheep (Ovis aries) Milk Whey Proteome and Comparison with Cow (Bos taurus) PLOS One DOI:10.1371/journal.pone.0139774 October 8th 2015
Clara S.F. Bah, Alaa El-Din A. Bekhit, Alan Carne, Michelle A. McConnell Production of Bioactive Peptide Hydrolysates from Deer, Sheep, and Pig Plasma Using Plant and Fungal Protease Preparations Food Chemistry 176: 54-63 (2015)
Clara SF Bah, Alaa El-din A Bekhit, Alan Carne, Michelle A McConnell Composition and biological activities of slaughterhouse blood from red deer, sheep, pig and cattle Journal of the Science of Food and Agriculture doi: 10.1002/jsfa.7062 (2015)
Jaydee D. Cabral, Michelle A. McConnell, Clare Fitzpatrick, Sonya Mros, Gail Williams, Peter J. Wormald, Stephen C. Moratti, Lyall R Hanton Characterization of the in vivo host response to a bi-labeled chitosan-dextran based hydrogel for postsurgical adhesion prevention Journal of Biomedical Materials Research Part A 12/2014 DOI: 10.1002/jbm.a.35395
Jaydee D. Cabral, Marina Roxburgh, Zheng Shi, Liqi Liu, Michelle McConnell, Gail Williams, Natasha Evans, Lyall R Hanton, Jim Simpson, Stephen C Moratti, Brian H Robinson, Peter J Wormald, Simon Robinson Synthesis, physiochemical characterization, and biocompatibility of a chitosan/dextran-based hydrogel for postsurgical adhesion prevention. Journal of Materials Science: Materials in Medicine DOI 10.1007/s10856-014-5292-3 (2014)
Sally D. Poppitt, Robin A. McGregor, Katy R. Weissing, Vimal K. Goyal, Amar J. Chitkara, Sarika Gupta, Kate Palmano, Barbara Kuhn-Sherlock and Michelle A. McConnell Bovine Complex Milk Lipid Containing Gangliosides for Prevention of Rotavirus Infection and Diarrhoea in Northern Indian Infants. Journal of Pediatric Gastroenterology and Nutrition 59 (2): 167-171 (2014)
Ha M, Bekhhit A, McConnell M, Mason S, Carne A Fractionation of whey proteins from red deer (Cervus elaphus) milk and comparison with whey proteins from cow, sheep and goat milks. Small Ruminant Research (125-134) (2014)
Aziz MA, Cabral JD, Brooks HJL, McConnell MA, Fitzpatrick C, Hanton LR, Moratti SC. In vitro biocompatibility and cellular interactions of a chitosan/dextran-based hydrogel used for postsurgical adhesion prevention. Journal of Biomedical Materials Research: Part B – Applied Biomaterials 00B:000–000. DOI: 10.1002/jbm.b.33206 (2014)
Clara S.F. Bah, Alaa El-Din A. Bekhit, Alan Carne and Michelle A. McConnell“Slaughterhouse Blood: An Emerging Source of Bioactive Compounds” Comprehensive Reviews in Food Science and Food Safety 12: 314-331 (2013)
Brooks HJL, McConnell MA, Broadbent RS. Microbes and the Inflammatory Response in Necrotising Enterocolitis (2013). In Preterm Birth ed. O. Erez, ISBN: 978-953-51- 0952-5 InTech, pp.137–174.http://www.intechopen.com/articles/show/title/microbes-and-the-inflammatory-response-in-necrotising-enterocolitis
Mros S, Ali MA, Bekhit A, McConnell M (2012). In vitro evaluation of the antimicrobial effects of chitosan against bacteria involved in ovine footrot. Proceedings of the New Zealand Society of Animal Production 72: 196-198
Vern Jou Cheng, Alaa El-Din A. Bekhit, Michelle McConnell, Sonya Mros, Jenny Zhao “Effect of extraction solvent, waste fraction and grape variety on the antimicrobial and antioxidant activities of extracts from wine residue from cool climate” Food Chem 134:474-482 (2012)
Alaa El-Din A. Bekhit, Vern Jou Cheng, Michelle McConnell, Jenny H. Zhao, Richard Sedcole, Roland Harrison"Antioxidant activities, sensory and anti-influenza activity of grape skin tea infusion." Food Chem 129: 837-845 (2011)
Bah, Clara Shui Fern; Fang, Evandro Fei; Ng, Tzi Bun; Mros, Sonya; McConnell, Michelle; Bekhit, Alaa el-din "Purification and characterization of a rhamnose-binding chinook salmon roe lectin with antiproliferative activity toward tumor cells and nitric oxide-inducing activity toward murine macrophages" Journal of Agricultural and Food Chemistry 59: 5720-5728 (2011)
Biological Acitivity of Lipid and Protein Derivatives from Bovine Milk on Human Rotavirus strain Wa in vitro M A McConnell, G Buchan, C, Fitzpatrick and A MacGibbon WO 2009/020405
Brooks H J L., McConnell M A, Corbett J, Buchan G S, Fitzpatrick C and Broadbent R S. Potential prophylactic value of bovine colostrum in necrotizing enterocolitis in neonates: an in vitro study on bacterial attachment, antibody levels and cytokine production. FEMS Immunol Med Microbiol 48: 347-354 (2006)
Davis C, McConnell M, Slobbe L, Haggarty N, Buchan G. Murine antigen-presenting cells are multifunctional in vitro biosensors for detecting the immunoactive potential of bovine milk products. JNutr 135(11) 2651-6 (2005)
Brooks H.J.L., Ahmed D., McConnell M.A., Barbezat G.O. Diagnosis of Helicobacter pylori infection by polymerase chain reaction: is it worth it? Diagnostic Microbiology and Infectious Disease 50: 1-5 (2004)
Ahmed D, Brooks H, McConnell M, Barbezat G. Antibiotic resistance in Helicobacter pylori: is it a problem in New Zealand? The New Zealand Medical Journal 117: 1-6 (2004)
McConnell, Michelle A, Glenn Buchan, Michail V Borissenko and Heather J L Brooks. A comparison of IgG and IgG1 activity in an early milk concentrate from non-immunised cows and a milk from hyperimmunised animals. Food Research International 34:255-261 (2001)