Next-generation sequencing, diagnostic microbiology, molecular microbiology, host-pathogen interaction, public health
My research focuses on the role of next-generation sequencing technologies in public health molecular microbiology. We are currently performing whole-genome sequencing of drug-resistant Mycobacterium tuberculosis clinical isolates for rapid diagnosis to direct effective treatment regimens.
My research also focuses on the development of new anti-TB drugs targeting bacterial metabolism and energetics. In particular, I am interested in identifying key regulatory networks that coordinate Mycobacterial metabolism.
H.L. Aung, W.W. Nyunt, Y. Fong, G.M. Cook and S.T. Aung, (2017) First two extensively drug-resistant tuberculosis cases from Myanmar treated with bedaquiline. Clinical Infectious Diseases 65(3):531-532.
H.L. Aung, T. Tun, W.W. Nyunt, Y. Fong, K.K. Thinn, J.A. Crump, S.T. Aung, and G.M. Cook, (2017) Association between anti-tuberculosis drug resistance-conferring mutations and treatment outcomes in Myanmar. Infectious Disease (In Press)
R. Mortuza, H.L. Aung, G. Taiaroa, H.K. Opel-Reading, T. Kleffmann, G.M. Cook and K.L. Krause (2017) Overexpression of a newly identified D-amino acid transaminase in Mycobacterium smegmatis complements glutamate racemase deletion. Molecular Microbiology (In Press)
Y. Nakatani, H.K. Opel-Reading, M. Merker, S.S. Kumar, D. Moradigaravand, F. Coll, D. Nair, K.R.U. Devi, T.A. Kohl, P. Beckert, S. Andres, G. Maphalala, D. Khumalo, R. Diel, K. Klaos, H.L. Aung, G.M. Cook, J. Parkhill, S.J. Peacock, S. Swaminathan, S. Niemann, K.L. Krause and C.U. Köser, (2017) Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance: Evolutionary, structural and biochemical evidence. Antimicrobial Agents and Chemotherapy (In Press)
W.W. Nyunt, S.T. Aung, G.M. Cook and H.L. Aung, (2017) Evaluation of the MTBDRsl test for detection of second-line resistance in drug-resistant Mycobacterium tuberculosis strains in Myanmar. Infectious Disease 49:11-12, 865-866.
C.V. Mulholland, A. Ruthe, R.T. Cursons, N. Karaus, K. Coley, J. Bower, E. Permina, M.J. Coleman, S.A. Roberts, V.L. Arcus, G.M. Cook and H.L. Aung, (2017) Rapid Diagnosis of the Mycobacterium tuberculosis Rangipo strain responsible for the largest recurring TB cluster in New Zealand. Diagnostic Microbiology and Infectious Disease 88:138-140.
W.W. Nyunt, S.T. Aung, T. Lwin, G.M. Cook and H.L. Aung, (2017) First- and second-line anti-tuberculosis drug resistance patterns among previous treatment failure patients in Myanmar. Journal of Global Antimicrobial Resistance 9:34-35.
H.L. Aung, T. Tun, E.Permina, W.W. Nyunt, S.T. Aung, T. Lwin, K.K. Thinn, J.A. Crump and G.M. Cook, (2016) Draft genome sequences of the drug-resistant Mycobacterium tuberculosis isolates from Myanmar. Genome Announcements 4: (5).
M. Petridis, C. Vickers, J. Robson, J. L. McKenzie, M. Bereza, A. Sharrock, H.L. Aung, V.L. Arcus and G.M. Cook, (2016) Structure and function of AmtR in Mycobacterium smegmatis: Implications for post-transcriptional regulation of urea metabolism through a small antisense RNA. Journal of Molecular Biology 428(21):4315-4329.
T. Tun, K. S. Aye, W.W. Nyunt, J.A. Crump, C. Nakajima, Y. Suzuki, K.K. Thinn, G.M. Cook and H.L. Aung, (2016) Genotypic diversity of Mycobacterium tuberculosis strains in Myanmar. Infectious Diseases 49(3):237-239.
T. Tun, K.Z. Latt, W.W. Nyunt, A.Samaranayaka, J.A. Crump, K.K. Thinn, G.M. Cook and H.L. Aung, (2016) Drug-resistant tuberculosis among previously treated patients in Yangon, Myanmar. International Journal of Mycobacteriology 5: 366-367.
H.L. Aung, T. Tun, D. Moradigaravand, C.U. Koser, W.W. Nyunt, S.T. Aung, T. Lwin, K.K. Thinn, J.A. Crump, J. Parkhill, S.J. Peacock, G.M. Cook and P.C. Hill, (2016) Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar. Journal of Global Antimicrobial Resistance 6: 113-117.
H.L. Aung, L. L. Dixon, L. J. Smith, N. P. Sweeney, J. R. Robson, M. Berney, R. Buxton, J. Green & G.M. Cook, (2015) Novel regulatory roles of cAMP receptor proteins (CRPs) in fast-growing environmental mycobacteria. Microbiology 161: 648-661.
H.L. Aung, C. Samaranayaka, R. Enright, K. Beggs & B. C. Monk, (2015) Characterisation of the DNA gyrase from the thermophilic eubacterium Thermus thermophiles. Protein Expression and Purification 107: 62-67.
H.L. Aung, D. Dey, R.S. Ronimus, P.H. Janssen & G.M. Cook, (2015) A high-throughput screening assay for identification of inhibitors of the A1AO-ATP synthase of the rumen methanogen Methanobrevibacter ruminantium M1. Journal of Microbiological Methods 110: 15-1.
H.L. Aung, M. Berney & G.M. Cook, (2014) Hypoxia-activated cytochrome bd expression in Mycobacterium smegmatis is cAMP receptor protein (CRP)-dependent. Journal of Bacteriology 196: 3091-3097.
D.G. McMillan, S.A. Ferguson, D. Dey, K. Schroder, H.L. Aung, V. Carbone, G.T. Attwood, R.S. Ronimus, T. Meier, P.H. Janssen & G.M. Cook, (2011) A1Ao-ATP synthase of Methanobrevibacter ruminantium couples sodium ions for ATP synthesis under physiological conditions. Journal of Biological Chemistry 286: 39882-39892.