1. Home
2. Our People
3. Teaching, Research and Support
4. Bacterial energetics

Bacterial energetics

Bacterial energetics as new target space for drug development

Our laboratory is focused on both fundamental and applied aspects of bacterial bioenergetics and translating this work into the development of new drugs targeting energy generation.

(see http://www.ncbi.nlm.nih.gov/pubmed/25476763)

Current work is also focused on determining the mode of action of new TB drugs against energetic targets including: bedaquiline, Q203 and SQ109. 

Priority targets include:

F₁F_o-ATP synthase

http://www.ncbi.nlm.nih.gov/pubmed/25754998

http://www.ncbi.nlm.nih.gov/pubmed/25575416

Non-proton translocating NADH dehydrogenase type II

http://www.ncbi.nlm.nih.gov/pubmed/24444429

http://www.ncbi.nlm.nih.gov/pubmed/26593449

http://www.ncbi.nlm.nih.gov/pubmed/25150092 

Succinate dehydrogenase

http://www.ncbi.nlm.nih.gov/pubmed/25412183

http://www.ncbi.nlm.nih.gov/pubmed/25118234

Cytochrome bd oxidase

http://www.ncbi.nlm.nih.gov/pubmed/26015371

http://www.ncbi.nlm.nih.gov/pubmed/25525207

http://www.ncbi.nlm.nih.gov/pubmed/24936051

 

---

Team members 

Dr Yoshio Nakatani, Research Fellow, yoshio.nakatani@otago.ac.nz

Dr Adam Heikal, Research Fellow, adam.heikal@otago.ac.nz

Dr Yosuke Shimaki, Assistant Research Fellow, yosuke.shimaki@otago.ac.nz

Kiel Hards, PhD candidate, kiel.hards@otago.ac.nz

Jessica Petri, PhD candidate, jessi@kleinvolk.de

Zoe Williams, PhD candidate, zoewilliams@hotmail.co.nz

Please enquire to obtain more specific information on these projects: gregory.cook@otago.ac.nz

 

---