1:00pm, Monday, 30th May
Room BIG13, Ground Floor
710 Cumberland St
Dr Martin Fronius
Department of Physiology, University of Otago
‘New roles for epithelial Na+ channel (ENaC) in the cardiovascular system and its potential contribution to COVID-19’
Being trained in biophysics Martin’s research focuses on the function and regulation of ion channels. Emphasis is on how mechanical forces (e.g., shears tress and pressure) regulate ion channel function of ENaC and Transient Receptor Potential Vanilloid (TRPV)) channels and how this influences arterial blood pressure regulation.
The seminar will present evidence for a new mechanism relying on N-glycans of ENaC that enable shear stress sensation and arterial blood pressure regulation. Further, the discovery of an yet unknown ENaC variant in human arteries will be shared and its potential implications for vascular physiology will be discussed. The last part of the presentation will explore ENaC's potential role in COVID-19 by introducing an ENaC centric perspective aiming to explain symptoms such as respiratory distress (and pulmonary oedema) and the loss of taste/smell.