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UPCOMING SEMINAR: Professor Joel Ernst, University of California

Posted by on 18 October 2018 | Comments

12.00pm Thursday, 18 October
Room 314, 3rd floor
Mathematics, Statistics and Physics Building
730 Cumberland St

Professor Joel Ernst
Division of Experimental Medicine
University of California
San Francisco
USA

The immunological challenges and opportunities of tuberculosis

Mycobacterium tuberculosis (the bacteria that cause TB) induces apparently robust innate and adaptive immune responses, yet those responses rarely if ever eliminate the bacteria. Since T cells (especially CD4 T cells) are essential for immune control of M. tuberculosis, and since the bacteria reside in professional antigen presenting cells, we have focused on identifying and characterising mechanisms used by the bacteria to manipulate antigen presenting cells and avoid elimination by T cell responses. Some of the mechanisms that will be discussed include: 1) delayed onset of T cell responses that allow 10,000-fold expansion of the bacterial population; 2) bacterial regulation of antigen gene expression; 3) bacterial interference with MHC class II antigen presentation by perturbing the ESCRT pathway and phagosome maturation; 4) export of bacterial antigens from infected cells, to evade T cell recognition of infected cells by antigen-specific CD4 T cells. The evolutionary and vaccine implications of these mechanisms will also be discussed.

This seminar is kindly sponsored by: The Australasian Society for Immunology Inc. (ASI)