12:00 Noon
Monday 3rd May
Room 208
Microbiology Bldg, 720 Cumberland Street
Dunedin
SEMINAR
Dr Allan Gamble
School of Pharmacy, University of Otago
‘Bioorthogonal chemical reactions for activation of prodrugs and diagnostics’
A bioorthogonal chemical reaction is a ‘click’ reaction between two carefully designed chemical reagents that can proceed, unhindered, in a living system. Traditionally these reactions have been used as ‘click-and-stick’ tools in chemical biology (e.g., bioconjugations and imaging). Our group is interested in designing ‘click-and-release’ type strategies for controlled drug delivery applications and diagnostics. We have identified a new and general bioorthogonal activation strategy based on the 1,3-dipolar cycloaddition of an azide-substituted self-immolative linker (SIL) and trans-cyclooctene (TCO). The development of this chemistry and the in vitro and in vivo applications using a tumour prodrug strategy will be presented. The ‘click-and-release’ approach could be extended to other areas of medicinal chemistry and chemical biology.
