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UPCOMING SEMINAR: Associate Professor Uri Hershberg, Philadelphia, USA

Posted by on 20 September 2018 | Comments

12.00pm Thursday, 20 September
Room 208
2nd floor, Microbiology Building
720 Cumberland St

Associate Professor Uri Hershberg
School of Biomedical Engineering, Science & Health Systems
Department of Microbiology & Immunology
College of Medicine
Drexel University

History will teach us something: immune system examples of the effects of different scales of selection pressure

The population of B cells in our body comprises ~ 10^ 9 different clones.  The progenitor of each clone is selected for receptor function following a unique recombination of its V(D)J gene segments. Thus, each clone has their own sets of specific B cells receptors, which are further diversified through mutation and selection during immune responses. I will present two studies that show how, by considering the patterns of mutation, diversification and expansion of B cell clones, we can tease out conditions in the body where selection differs and how it can influence diversification and selection across multiple time scales. The B cell clone is uniquely suited for such analysis as, unlike in most studies of gene evolution, we can identify both the mutant and its germline source. Analysing high throughput sequencing experiments that allowed us to consider millions of clones from tens of individuals in different human populations, I will describe the clear division of B cell repertoires between gut and blood tissues, as well as the special influence of serine codon usage on serine substitutions patterns. The latter of which influences both somatic and germline selection process in B cells but also in general in evolution.

This seminar is kindly sponsored by: The Australasian Society for Immunology Inc. (ASI)