Our laboratory is focused on three fundamental aspects of Mycobacterial physiology:
1. Determining how Mycobacterium tuberculosis and other pathogenic microorganisms metabolize and generate energy in host tissues
• What energy sources do pathogenic microorganisms use in the host?
• What are the mechanisms that pathogenic microorganisms use to generate energy?
• How do aerobic pathogens survive in host tissues that are hypoxic?
• What are the signaling pathways and how are the controlled?
2. Deciphering the mechanisms Mycobacterium tuberculosis uses to slow metabolism/growth in response to various environmental cues
• How do mycobacteria uncouple metabolism from growth?
• What role do toxin-antitoxin modules play in this process?
3. Energetics of M. tuberculosis growth: a new area for drug discovery
• What are the pathways used by mycobacteria to generate energy during aerobic and hypoxic growth?
• Determining the structures to atomic resolution of enzymes involved in generating energy in M. tuberculosis (e.g. ATP synthase, NADH dehydrogenase II, menaquinone biosynthesis enzymes, cytochrome bd)
Please enquire to obtain more specific information on these projects: Gregory.firstname.lastname@example.org
Dr Michael Berney, Research Fellow, email@example.com
Dr Jennifer Robson, firstname.lastname@example.org
Dr Adam Heikal, email@example.com
Dr Idiko Pecsi, firstname.lastname@example.org
Lara Pfister, email@example.com
Mr Htin Aung, PhD candidate, firstname.lastname@example.org
Ms Nandula Ekanayaka, PhD candidate, email@example.com
Mr Chris Greening, PhD Candiate, firstname.lastname@example.org
Ms Elyse Dunn, PhD candidate, email@example.com
Mr Michael Petridu, PhD candidate, firstname.lastname@example.org
Kiel Hards, BSc(Hons) student, email@example.com
Kieran Jongerius, Summer student, firstname.lastname@example.org