MICR 337: Virology
18 points - Semester 2
How viruses recognise and infect cells. Molecular aspects of viral replication. How viruses interact with the host and cause disease with emphasis on contemporary human viral diseases.
Viruses cause a wide array of diseases from influenza to polio to rhabies. They are intracellular pathogens that must infect a host and manipulate it to their own purposes, while completing their replication and escaping their hosts to spread. The amazing diversity of viruses is underpinned by central themes of cell entry, genome replication, gene expression, virus assembly and dissemination.
The virology paper will give you an integrated and fundamental understanding of the principles of viruses and viral replication and their intimate interactions with the host they infect, including:
- how viruses select and enter specific cells.
- the molecular basis of how viruses control their own replication and the hosts they infect.
- examination of the cellular and systemic effects of viral infection on the host.
This course is for students wanting a core paper on virology that includes course and team work on contemporary issues in virology from current diseases through to host-virus interactions, including a lab course where you isolate, characterise and visualise by electron microscopy, your own virus.
Lecture course overview
During the MICR 337 lecture course you will:
- explore the process of cell attachment, entry and uncoating, viral coordination of assembly and viral egress from the host cell
- undertake team studies on contemporary issues in virology
- examine RNA and DNA virus replication processes
- look at viral interactions with and manipulation of the host
- learn about particles such as prions and viroids
Lab course overview
You will isolate your own virus from an environmental sample, characterise its growth, determine its host range and purify your own isolate by ultracentrifugation for analysis by electron microscopy.
- Group presentation and individual essay on a contemporary topic in Virology (10%)
- Lab assessment (20%)
- Final exam (70%)
One of MICR 221, 223, 201, GENE 221 or 211
Thursday 13:00 – 13:50 pm, Friday 11:00 – 11:50 am
Tuesday 14:00 – 17:50, Wednesday 09:00 – 17:50*
*you can leave the Wednesday lab session to attend other courses as needed.
Virology labs run weeks 9 – 12 of Semester 2.
There will be also be small amounts of work required on additional days of the week but this can be worked around other class commitments.
Note: there are no lecture or practical clashes between any of the 300-level MICR papers
Introduction to Modern Virology, Dimmock et al. (6th Edition) 2007
Alternate reference texts:
Principles of Virology, Flint et al (2nd or 3rd edition)
or Principles of Molecular Virology, Alan Cann (4th edition) 2005
- Dr Matloob Husain (Course Convenor) »
- Professor Vernon Ward »
- Professor Andy Mercer »
- Dr Rita Przybilski
For more information on this course, please contact the Course Convenors Vernon Ward (firstname.lastname@example.org) and Matloob Husain (email@example.com) or the 3rd year Teaching Fellow Rita Przybilski (479-8475, micro300level.TF@otago.ac.nz)
To find out information on the fees and other information on this paper, click here.